Prof. Yongfeng Shang


 
 

 

 

Yongfeng Shang, Ph.D.

Academician of Chinese Academy of Sciences

 

PhD: The Pennsylvania State University

Postdoctoral training: Dana-Farber Cancer Institute, Harvard Medical School

 

Contact:

Phone: 86-10-82805118 (O)

     86-10-82801397 (L)

Fax:   86-10-82801355

Email: yshang@hsc.pku.edu.cn

 

Research Interest

  The researches in our lab are three-fold: 1) Molecular mechanisms involved in the tumorigenesis of breast cancer and endometrial cancer; 2) Epigenetic mechanisms for gene regulation; and 3) Molecular cloning and functional characterization of novel human genes. Over the years, our work have been published in journals such as Cell, Nature, Science, Nature Reviews Cancer, Nature Genetics, Cancer Cell, Genes & Development, Molecular Cell, etc.

 

Recent Publications (*Corresponding author)

1. Yu Zhang, Di Zhang, Qian Li, Jing Liang, Luyang Sun, Xia Yi, Zhe Chen, Ruorong Yan, Guojia Xie, Wanjin Li, Shumeng Liu, Bosen Xu, Lei Li, Jianguo Yang, Lin He, and Yongfeng Shang* (2016). Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering. Nature Genetics 48, 1003-1013    PDF

2. Lei Li, Lan Shi, Shangda Yang, Ruorong Yan, Di Zhang, Jianguo Yang, Lin He, Wanjin Li, Xia Yi, Luyang Sun, Jing Liang, Zhongyi Cheng, Lei Shi, Yongfeng Shang*, and Wenhua Yu* (2016). SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability. Nature Communications 7:12235/DOI: 10.1038/ncomms12235    PDF

3. Lin Shan, Xing Zhou,  Xinhua Liu, Yue Wang, Dongxue Su, Yongqiang Hou, Na Yu, Chao Yang, Beibei Liu, Jie Gao, Yang Duan, Jianguo Yang, Wanjin Li, Jing Liang, Luyang Sun, Kexin Chen, Chenghao Xuan, Lei Shi, Yan Wang, Yongfeng Shang*(2016). FOXK2 elicits massive transcription repression and suppresses the hypoxic response and breast cancer carcinogenesis. Cancer Cell 30(5):708-722    PDF

4. Wenzhe Si, Wei Huang, Yu Zheng, Yang Yang, Xujun Liu, Lin Shan, Xing Zhou, Yue Wang, Dongxue Su, Jie Gao,Ruorong Yan, Xiao Han, Wanjin Li, Lin He, Lei Shi, Chenghao Xuan, Jing Liang, Luyang Sun, Yan Wang, and Yongfeng Shang* (2015). Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis. Cancer Cell 27: 822–836    PDF

2. Ruorong Yan, Lin He, Zhongwu Li, Xiao Han, Jing Liang, Wenzhe Si, Zhe Chen, Lei Li, Guojia Xie, Wanjin Li, Peiyan Wang, Liandi Lei, Hongquan Zhang, Fei Pei, Dengfeng Cao, Luyang Sun*, and Yongfeng Shang* (2015). SFCJFK is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer. Genes & Debelopment 29: 672-685    PDF

3. Xiao Han, Bin Gui, Cong Xiong, Linnan Zhao, Jing Liang, Luyang Sun, Xiaohan Yang, Wenhua Yu, Wenzhe Si, Ruorong Yan, Xia Yi, Di Zhang, Wanjin Li, Lifang Li, Jianguo Yang, Yan Wang,Yi Eve Sun, Dai Zhang, Anming Meng, Yongfeng Shang* (2014) Destabilizing LSD1 by Jade-2 Promotes Neurogenesis: An Antibraking System in Neural Development. Molecular Cell 55(3): 482-494    PDF

4. Xin Li, Ling Liu, Shangda Yang, Nan Song, Xing Zhou, Jie Gao, Na Yu, Lin Shan, Qian Wang, Jing Liang, Chenghao Xuan, Yan Wang, Yongfeng Shang*, and Lei Shi* (2014). Histone demethylase KDM5B is a key regulator of genome stability.ProcNatlAcadSci USA.111: 7096-7101    PDF

5. Feng Wang, Lin He, Peiwei Huangyang, Jing Liang, Wenzhe Si, Ruorong Yan, Xiao Han, Shumeng Liu, Bin Gui, Wanjin Li, Di Miao, Chao Jing, Zhihua Liu, Fei Pei, Luyang Sun*, Yongfeng Shang* (2014) JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation. PLoS Biology 12(3): e1001819. doi:10.1371/ journal.pbio.1001819    PDF

6. Chenghao Xuan*, Qian Wang, Xiao Han, Yang Duan, Xin Li, Lei Shi, Yan Wang, Lin Shan, Zhi Yao, and Yongfeng Shang* (2013). RBB, a novel transcription repressor the transcription of HDM2 oncogene. Oncogene 32:3711-3721    PDF

7. Peiwei Huangyang, Yongfeng Shang* (2013). Epigenetic regulation of epithelial to mesenchymal transition. Current Cancer Drug Targets 13:973-85

8. Xiaohan Yang, Lei Li, Jing Liang, Lei Shi, Jianguo Yang, Xia Yi, Di Zhang, Xiao Han, Na Yu,Yongfeng Shang* (2013). Histone Acetyltransferase 1 Promotes Homologous Recombination in DNA Repair by Facilitating Histone Turnover. Journal of Biological Chemistry 288(25):18271-82     PDF

9. Jing Liang, Yongfeng Shang* (2013). Estrogen and cancer. Annual Review of Physiology 75:225-40    PDF

10. Yan Wang, Yongfeng Shang* (2013). Epigenetic control of epithelial-to-mesenchymal transition and cancer metastasis, Experimental Cell Research 319: 160-9    PDF

11. Fen Yang, Luyang Sun, Qian Li, Xiao Han, Liandi Lei, Hua Zhang*, and Yongfeng Shang* (2012). SET8 promotes epithelial-mesenchymal transition and confers Twist dual transcriptional activities. The EMBO Journal 31: 110-23    PDF

12. Xia Yi, Mei Hong, Bing Gui, Zhe Chen, Lei Li, Guojia Xie, Jing Liang, Wang X, Shang Y* (2012). RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway. Journal of Biological Chemistry 287(25):21045-57    PDF

13. Dandan Wang, Jing Liang, Yu Zhang, Bin Gui, Feng Wang, Xia Yi, Luyang Sun, Zhi Yao, Yongfeng Shang* (2012). Steroid Receptor Coactivator-interacting Protein (SIP) Inhibits Caspase-independent Apoptosis by Preventing Apoptosis-inducing Factor (AIF) from Being Released from Mitochondria. Journal of Biological Chemistry 287(16): 12612-21    PDF

14. Xiaohan Yang, Wenhua Yu, Lei Shi, Luyang Sun, Jing Liang, Xia Yi, Qian Li, Yu Zhang, Fen Yang, Xiao Han, Di Zhang, Jie Yang, Zhi Yao, and Yongfeng Shang* (2011). HAT4, a Golgi Apparatus-anchored B-type Histone Acetyltransferase, Acetylates Free Histone H4 and Facilitates Chromatin Assembly. Molecular Cell 44: 39-50    PDF

15. Qian Li, Lei Shi, Bin Gui, Wenhua Yu, Jiamu Wang, Di Zhang, Xiao Han, Zhi Yao, and Yongfeng Shang* (2011). Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14. Cancer Research 71: 6899-908    PDF

16. Lei Shi, Luyang Sun, Qian Li, Jing Liang, Wenhua Yu, Xia Yi, Xiaohan Yang, Yanyan Li, Xiao Han, Yu Zhang, Chenghao Xuan, Zhi Yao, and Yongfeng Shang* (2011). Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proc Natl Acad Sci U S A. 108: 7541-7546    PDF

17. Yanyan Li, Luyang Sun, Yu Zhang, Dandan Wang, Feng Wang, Jing Liang, Bin Gui, and Yongfeng Shang* (2011). The histone modifications governing TFF1 transcription mediated by estrogen receptor. Journal of Biological Chemistry 286: 13925-13936    PDF

18. Luyang Sun, Lei Shi, Feng Wang, Peiwei Huangyang, Wenzhe Si, Jie Yang, Zhi Yao*, and Yongfeng Shang* (2011). Substrate Phosphorylation and Feedback Regulation in JFK-promoted p53 Destabilization. Journal of Biological Chemistry 286: 4226-4235    PDF

19. Yu Zhang, Jing Liang, Yanyan Li, Chenghao Xuan, Feng Wang, Dandan Wang, Lei Shi, Di Zhang, and Yongfeng Shang* (2010). CCCTC-binding Factor Acts Upstream of FOXA1 and Demarcates the Genomic Response to Estrogen. Journal of Biological Chemistry 285: 28604–28613    PDF

20. Wenhua Yu, Ruifang Li, Bin Gui, and Yongfeng Shang* (2010). sZIP, an Alternative Splice Variant of ZIP, Antagonizes Transcription Repression and Growth Inhibition by ZIP. Journal of Biological Chemistry 285: 14301-14307    PDF

21. Yan Wang, Hua Zhang, Yupeng Chen, Yimin Sun, Fen Yang, Wenhua Yu, Jing Liang, Luyang Sun, Xiaohan Yang, Lei Shi, Ruifang Li, Qian Li, Xia Yi, and Yongfeng Shang* (2009). LSD1 is a Subunit of the NuRD complex and Targets the Metastasis Programmes in Breast Cancer. Cell 138: 660-672    PDF

22. Luyang Sun, Lei Shi, Wenqian Li, Wenhua Yu, Jing Liang, Hua Zhang, Xiaohan Yang, Yan Wang, Ruifang Li, Xingrong Yao, Xia Yi, and Yongfeng Shang* (2009). JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation. Proc Natl Acad Sci U S A. 106: 10195-10200    PDF

23. Ruifang Li, Hua Zhang, Wenhua Yu, Yupeng Chen, Bin Gui, Jing Liang, Yan Wang, Luyang Sun, Xiaohan Yang, Yu Zhang, Lei Shi, Yanyan Li, and Yongfeng Shang* (2009). ZIP: a Novel Transcription Repressor, Represses EGFR Oncogene and Suppresses Breast Carcinogenesis. The EMBO Journal 28: 2763-2776    PDF

24. Jing Liang, Hua Zhang, Yu Zhang, Ying Zhang, and Yongfeng Shang* (2009). GAS, a new glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function. EMBO reports 10: 51-57    PDF

25. Yupeng Chen, Lei Shi, Lirong Zhang, Ruifang Li, Jing Liang, Wenhua Yu, Luyang Sun, Xiaohan Yang, Yan Wang, Yu Zhang, and Yongfeng Shang* (2008). The Molecular Mechanism Governing the Oncogenic Potential of SOX2 in Breast Cancer. Journal of Biological Chemistry 283: 17969-17978    PDF

26. Dongwei Fan, Zhongqiang Chen*, Yupeng Chen, and Yongfeng Shang* (2007). Mechanistic Roles of Leptin in Osteogenic Stimulation in Thoracic Ligament Flavum Cells. Journal of Biological Chemistry 282: 29958-29966    PDF

27. Xin Li, Jing Liang, Haijing Yu, Bing Su, Chunjie Xiao, Yongfeng Shang*, Wen Wang* (2007). Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes. Trends in Genetics 23: 427-431    PDF

28. Bin Shi1, Jing Liang1, Xiaohan Yang, Yan Wang, Youna Zhao, Huijian Wu, Luyang Sun, Ying Zhang, Yupeng Chen, Ruifang Li, Yu Zhang, Mei Hong, and Yongfeng Shang* (2007) . Integration of Estrogen and Wnt Signaling Circuits by the Polycomb Group Protein EZH2 in Breast Cancer Cells. Molecular and Cellular Biology 27: 5105-5119    PDF

29. Ying Zhang, Hua Zhang, Jing Liang, Wenhua Yu, and Yongfeng Shang* (2007). SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. The EMBO Journal 26: 2645-2657    PDF

30. Shaosi Li, Yongfeng Shang* (2007). Regulation of SRC Family Coactivators by Post-translational Modifications. Cellular Signalling 19: 1101-1112 (invited review)    PDF

31. Yongfeng Shang* (2007). Hormones and cancer. Cell Research 17: 277-279    PDF

32. Hua Zhang, Luyang Sun, Jing Liang, Wenhua Yu, Ying Zhang, Yan Wang, Yupeng Chen, Ruifang Li, Xiaojing Sun, and Yongfeng Shang* (2006). The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription. The EMBO Journal 25: 4223-4233    PDF

33. Huijian Wu, Luyang Sun, Ying Zhang, Yupeng Chen, Bin Shi, Ruifang Li, Yan Wang, Jing Liang, Dongwei Fan, Ge Wu, Dan Wang, Shaosi Li, and Yongfeng Shang* (2006). Coordinated Regulation of AIB1 Transcriptional Activity by Sumoylation and Phosphorylation. Journal of Biological Chemistry 281: 21848-21856    PDF

34. Yongfeng Shang* (2006). Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis. Nature Reviews Cancer 6: 360-368 (invited review)    PDF

35. Huijian Wu, Yupeng Chen, Jing Liang, Bin Shi, Ge Wu, Ying Zhang, Dan Wang, Ruifang Li, Xia Yi, Hua Zhang, Luyang Sun, and Yongfeng Shang* (2005). Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis. Nature 438: 981-987    PDF

36. Hua Zhang, Xia Yi, Xiaojing Sun, Na Yin, Bin Shi, Huijian Wu, Dan Wang, Ge Wu, and Yongfeng Shang* (2004). Differential Gene Regulation by the SRC Family of Coactivators. Genes and Development 18: 1753-1765    PDF

37. Na Yin, Dan Wang, Hua Zhang, Xia Yi, Xiaojing Sun, Bin Shi, Huijian Wu, Ge Wu, Xinjuan Wang, and Yongfeng Shang* (2004). Molecular Mechanisms Involved in the Growth Stimulation of Breast Cancer Cells by Leptin. Cancer Research 64: 5870-5875    PDF

38. Xiaojing Sun, Hua Zhang, Dan Wang, Yan Shen*, and Yongfeng Shang* (2004). DLP, A Novel Dim1 Family Protein Implicated in Pre-mRNA Splicing and Cell Cycle Progression. Journal of Biological Chemistry 279: 32839-32847    PDF

39.  Ma Han, Yongfeng Shang, DY Lee, and Michael Stallcup (2003). Study of nuclear receptor-induced transcription complex assembly and histone modification by chromatin immunoprecipitation assays. Methods in Enzymology 364: 284-296

40. Zebin Mao, Song Shan, Yunyan Zhu, Xia Yi, Hua Zhang, Yongfeng Shang*, and Tanjun Tong* (2003). Transcriptional Regulation of A33 Antigen Expression by Gut-enriched Krüppel-like Factor (GKLF). Oncogene 22: 4434-4443    PDF

41. Yongfeng Shang and Myles Brown (2002). Molecular determinants for the tissue specificity of SERMs. Science 295: 2465-2468    PDF

42. Yongfeng Shang, Molly Myers and Myles Brown (2002). The formation of androgen receptor transcription complex. Molecular Cell 9: 601-610    PDF

43. Maricarmen D. Planas-Silva, Yongfeng Shang, Joana Liu Donaher, Myles Brown, and Robert A. Weinberg (2001). AIB1 enhances estrogen- dependent induction of cyclin D1 expression. Cancer Research 61: 3858-3862    PDF

44. Yongfeng Shang, Xiao Hu, James Direnzo, Mitch Lazar, and Myles Brown (2000). Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103: 843-852    PDF

45. James DiRenzo, Yongfeng Shang, Michael Phelan, Said Sif, Molly Yancisin, Robert Kingston, and Myles Brown (2000). BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation. Molecular and Cellular Biology 20: 7541-7549    PDF

46. Yongfeng Shang, Craig R. Baumrucker, and Michael H. Green (1999). Induction and activation of signal transducer and activator of transcription (STAT) 1 by all-trans-retinoic acid in breast cancer cells is mediated by RARb signaling pathways. Oncogene 18: 6725-6732    PDF

47. Yongfeng Shang, Craig R. Baumrucker, and Michael H. Green (1999). Signal relay by RARa and RARb in retinoic acid-induced IGFBP3 expression in breast cancer cells. Journal of Biological Chemistry 274: 18005-18010    PDF

48. Yongfeng Shang, Craig R. Baumrucker, and Michael H. Green (1998). c-Myc is a major mediator of the synergistic growth inhibitory effects of retinoic acid and interferon in breast cancer cells. Journal of Biological Chemistry 273: 30608-30613    PDF 

  

Lab Members

Staff

 

Yongfeng Shang

Professor

Email: yshang@hsc.pku.edu.cn

Jing Liang

Associate Professor

Email: liang_jing@hsc.pku.edu.cn

Luyang Sun

Associate Professor

Email: luyang_sun@hsc.pku.edu.cn

Xia Yi

Associate Professor

Email: yixia@hsc.pku.edu.cn

Xiaohan Yang

Lecturer

Email: xiaohanyan@hsc.pku.edu.cn

Dan Wang

Senior Technician

Email: wd@hsc.pku.edu.cn

Ge Wu

Assistant

Email: wuge@hsc.pku.edu.cn

 

 

Students

 

Wanjin Li

Ph.D. Student

Email: wanjin_li@hsc.pku.edu.cn

Shumeng Liu

Ph.D. Student

Email: shumeng@hsc.pku.edu.cn

Lin He

Ph.D. Student

Email: linhe@hsc.pku.edu.cn

Jianguo Yang

Ph.D. Student

Email: yangjianguo@hsc.pku.edu.cn

Bosen Xu

Ph.D. Student

Email: bsxu@hsc.pku.edu.cn

Xia Ting

Ph.D. Student

Email: tingxia@hsc.pku.edu.cn

Xujun Liu

Ph.D. Student

Email: xujunliu@hsc.pku.edu.cn

Chongyang Wu

M.S. Student

Email: wuchongyang@hsc.pku.edu.cn

Tong Jin

Ph.D. Student

Email: tjin@hsc.pku.edu.cn

Zihan Zhang

Ph.D. Student

Email: zhangzihan@hsc.pku.edu.cn

Ziran Yang

M.S. Student

Email: ziranyang@hsc.pku.edu.cn

Wenting Zhang

Ph.D. Student

Email: zhangwenting@hsc.pku.edu.cn

Huajing Yu

M.S. Student

Email: huajingyu@hsc.pku.edu.cn

Hanxiao Li

M.S. Student

Email: lhxlihanxiao@hsc.pku.edu.cn

Yunchao Huang

Ph.D. Student

Email: ychaohuang@hsc.pku.edu.cn

Jie Ren

M.S. Student

Email: sylarren@hsc.pku.edu.cn

 

 Past Members

 

Huijian Wu

Postdoc

Bin Shi

Postdoc

Mei Hong     

Postdoc

Chenhao Xuan

Postdoc

Yu Zhang

Postdoc

Bin Gui

Postdoc

Xiaojing Sun

Ph.D.

Na Yin

M.S.

HuaZhang

Ph.D.

Ying Zhang

Ph.D.

Dongwei Fan

Ph.D.

Yupeng Chen

Ph.D.

Yan Wang

Ph.D.

Ruifang Li

Ph.D.

Lei Shi

Ph.D.

Qian Li

Ph.D.

Fen Yang

Ph.D.

Yanyan Li

Ph.D.

Dandan Wang

Ph.D.

Feng Wang

Ph.D.

Di Zhang

Ph.D.

Na Yu

Ph.D.

Zhipeng Yu

Ph.D.

Xiao Han

Ph.D.

Wenzhe Si

Ph.D.

Ruorong Yan

Ph.D.

Lei Li

Ph.D.

Yongqing Liu

M.S.

Lan Shi

M.S.

Guojia Xie

Ph.D.

Zhe Chen

Ph.D.

Lifang Li

Ph.D.

Shuai Yuan

M.S.

 
   

 

 

 

Photoes

 

 

Prof. Shang

 

Defense for PhD

 

 

Members of the lab photoed with Dr. Robert Weinberg

 

Prof. Shang

 

 

Lab Outing

 

 

 

 


 
 
     
     
     



 

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Peking University Health Science Center
Phone 86-10-82801144(L) 86-10-82802417(O)